Evaluación toxicológica de los extractos metanólicos de peperomia sp y otholobium mexicanum mediante la técnica de toxicidad aguda en embriones de peces en el modelo de danio rerio.

Abstract

The use of medicinal plants is a traditional practice in various parts of the world, including Ecuador, where the species of Peperomia sp and Otholobium mexicanum are usually used in traditional medicine for the treatment of various conditions. However, despite the widespread use in the population, studies related to toxicity of these plants are scarce or null. For this reason, the present study evaluated the toxicity and teratogenicity of the methanolic extracts of Peperomia sp and Otholobium mexicanum using the criteria established in document number 236 of the Organization for Economic Cooperation and Development (OECD), obtaining the lethal concentration 50 (LC50) of 4.7556 μg/mL for Peperomia sp and 5.0282 μg/mL for Otholobium mexicanum, in the case of teratogenicity in the two plants all the established teratogenicity criteria could be evidenced. These results allow us to conclude that the methanolic extracts of the two study plants are toxic and teratogenic for the organisms used as experimental models.