Biomarcadores trombo inflamatorios de valor pronóstico en la progresión a COVID-19 severo en pacientes mayores a 18 años

Abstract

The respiratory infection caused by SARS-CoV-2 was declared as pandemic in March 2022, due to high levels of contagious, spreading, and unpredictable clinic path, representing as a scientific challenge about investigation towards a scientific level, medical and clinic diagnostic. A significative percentage of cases, the disease could have a quick advance and progress to a several condition, developing complications that can lead to deadly consequences. A vast analysis of different lab parameters along with checking of vital signs and symptoms allow to identify which state of the disease the patients are, so it would allow to give a timely attention required to anticipate towards a worst scenario. This research was aimed to analyze the usefulness of inflammatory and infectious indicators was analyzed as C-reactive protein (CRP), procalcitonin (PCT), ferritin and D-dimer as a coagulation marker, and the prognostic value that all of them represent in the spread of COVID-19. In the following scientific literature review a search was carried out on diverse digital scientific sources of the available information published during the sanitary emergency “pandemic”. The patients participating in the selected studies presented a positive diagnosis for SARS-CoV-2 and were older than 18 years. Results showed that a measurement of ferritin higher than 828 ng/mL is associated with severity and higher than 1700 ng/mL with mortality, the CRP value higher than 108 mg/L is associated with a severe disease, PCT is not associated only with coinfection, but increased values are related to a poor prognosis and the D-dimer increased 10 times more than the reference range is associated with thromboembolic complications. In conclusion, these biomarkers are useful and applicable as an independent factor for predicting mortality and severity in patients with COVID-19.