Queratoquiste odontogénico: ¿tumor o quiste? revisión de la literatura

Abstract

Background: The odontogenic keratocyst (OKC), initially described as a developmental cyst that comes from the dental lamina or its remnants, has undergone changes in its terminology and classification due to clinical variations and genetic discoveries, although it was proposed as a benign neoplasm in 1967, recent evidence leads to a new classification as odontogenic keratocyst in the WHO edition in 2017. Objective: To analyze the current evidence on OKC taking into account its radiographic, clinical, histopathological and molecular aspects to determine its current nature. Methods: A bibliographic search was carried out in the PubMed, Scopus, Scielo and Science direct databases for comprehensive review. The search was limited to the English, Portuguese and Spanish languages; open access articles; systematic review, meta-analysis and randomized clinical trials. Results: The study analyzed 19 articles that addressed various characteristics of odontogenic keratocyst, including recurrence, clinical and radiographic features, WHO updates, genetic influence, expression of markers, and comparisons with other odontogenic cysts/tumors. Conclusion: OKC is an uncertain pathology since the uncertainty regarding the designation of OKC as a cyst or neoplasm seems to be far from being resolved.