Eficacia y seguridad del ácido hialurónico como monoterapia o combinado con corticoides para el tratamiento de la gonartrosis. Revisión bibliográfica

Abstract

Background: Gonarthrosis is common in older adults, being a common cause of morbidity and mortality, deterioration in quality of life and significant disability. Studies mention that hyaluronic acid alone or combined with corticosteroids relieves pain and promotes the recovery of joint function in acute-moderate gonarthrosis. Objective: To identify the efficacy and safety of the use of hyaluronic acid as monotherapy or combined with corticosteroids in patients with acute- moderate gonarthrosis through a literature review. Methodology: Narrative literature review study on the use of hyaluronic acid with or without corticosteroids for gonarthrosis. An information search was carried out in PubMed, Scopus, Scielo and Science. direct, through the PICO search strategy, Boolean operators and advanced search filters. The GRADE and AMSTAR-2 scale were used to evaluate the quality of the studies. Results: 8 studies (7 meta-analysis and 1 clinical trial) were selected for data extraction, they indicated that both hyaluronic acid and corticosteroids reduce pain and have short-term adverse effects with spontaneous resolution. The evidence found was of high and moderate quality. Conclusion: High molecular weight hyaluronic acid, which has a delayed but prolonged effect, and extended-release corticosteroids, which act quickly but for short duration, were shown to improve pain scores in WOMAC and VAS after 3 months , with the possibility of further improvement at 12 months. The treatments were proven safe with few adverse reactions