Frecuencia de marcadores moleculares en leucemia mieloide caracterizada por citometría de flujo en pacientes de SOLCA 2015-2019

Abstract

Background: Flow cytometry is a rapid, objective and quantitative method of analysis of cellular physical/chemical characteristics, a very useful technique in the diagnosis of leukemia and its classification by cellular immunophenotyping. General Objective: To describe the frequency of molecular markers in myeloid leukemia characterized by flow cytometry in SOLCA patients, 2015 - 2019. Methodology: The present study was a cross-sectional descriptive study whose universe consisted of all complete medical records of patients diagnosed with AML in the period 2015-2019 in SOLCA/Cuenca. The demographic data of each patient who underwent testing for AML molecular markers by Flow Cytometry and PCR was analyzed. Data were collected through the SOLCA information system, interpretation of the information was performed using statistical tables and graphs. Results: The cases analyzed in the study ranged in age from 0 to 90 years, with the most frequent ages ranging from 11 to 20 years. The province with more cases was Azuay. Of the cases analyzed 55 were female and 52 were male, 40 cases with a diagnosis of AML presented the M3 subtype being the most frequent in the study, the predominant cell marker was CD33 with positivity in 103 cases and the most frequent chromosomal alteration detected was PML/RARa t(15;17) with presence in 29 cases.