Interacciones medicamento nutriente y medicamento planta medicinal en el tratamiento farmacológico de la hipertensión arterial con losartán: revisión sistemática cualitativa

Abstract

Background: In 1927, Burrows and Farr demonstrated an interaction between b-carotenes and mineral oil (laxative), but it was not until 2000 that the importance of this type of interactions was recognized, considering them as a public health problem (1,2), which can potentiate or inhibit the pharmacological effect of the drug with significant clinical relevance (3,5). Therefore, it is essential to have sufficient data in order to provide an adequate prescription that achieves a successful treatment.

Objective: to synthesize the scientific evidence on the clinically relevant aspects of the drug- nutrient and drug-medicinal plant interactions in the pharmacological treatment of

hypertension with losartan. Methodology: Qualitative systematic review of primary origin articles on the reported interactions between nutrients or medicinal plants and losartan. Results: When the search equations were applied, 283 articles were reached, and three that met the inclusion criteria were analyzed. In the first, no interaction was reported between losartan and red ginseng, in the second there is an interaction of increased toxicity between Rhodiola rosea and losartan, finally in the third, a pharmacokinetic absorption interaction was reported between losartan and a diet rich in fat and calories. Conclusions: The administration of losartan with the medicinal plant Rhodiola rosea and a food rich in fats and calories causes pharmacokinetic-type drug interactions, increasing the absorption of the drug and, consequently, generating toxicity associated with high plasma concentrations.

Keywords: High blood pressure. Losartan. Drug interaction. Drug-nutrient interaction. Drug- medicinal plant interaction.