Eficacia de racecadotrilo en el tratamiento de la enfermedad diarreica aguda en niños de 3 a 36 meses en el servicio de emergencia del Hospital Vicente Corral Moscoso. Ensayo clínico controlado ciego. 2014

Abstract

Objectives: to determine the efficacy of combined treatment with ORS and Racecadotril against the use of ORS and placebo in children 3 to 36m with acute diarrhea in the Vicente Corral Moscoso Hospital emergency service. Methodology: blind controlled clinical trial in children aged 3-36 months of emergency service HVCM, with acute diarrhea without dehydration or mild to moderate dehydration, which do not require hospitalization, without prior antibiotic or antidiarrheal treatment, whose parents or legal representatives signed informed consent. 79 patients were enrolled, 45 in the racecadotril group and 34 ORS plus placebo group. Results: the groups were comparable clinically, patients in the ORS's plus racecadotril showed a significant difference in the number of diarrhea per day from 48 hours 2.7 (SD: ± 1.5) and placebo group plus ORS 4.1 (SD: ± 2.6) p: 0.012; at 72 hours racecadotril group 2,2 (ds: ± 1.7), placebo 3.3 (SD: ± 2.5) p: 0.027; not significant difference was found in the first 24 hours p: 0.27. No significant differences were found in medical revisit or hospitalizations. Conclusions: racecadotril is effective in reducing the number of diarrhea after 48 hours in the initial treatment of children with AG accompanying ORS therapy in our midst